Article Dans Une Revue Psychological Medicine Année : 2023

Decision-making under risk and ambiguity in adults with Tourette syndrome

Résumé

Background Tourette syndrome (TS) as well as its most common comorbidities are associated with a higher propensity for risky behaviour in everyday life. However, it is unclear whether this increased risk propensity in real-life contexts translates into a generally increased attitude towards risk. We aimed to assess decision-making under risk and ambiguity based on prospect theory by considering the effects of comorbidities and medication. Methods Fifty-four individuals with TS and 32 healthy controls performed risk and ambiguity decision-making tasks under both gains and losses conditions. Behavioural and computational parameters were evaluated using (i) univariate analysis to determine parameters difference taking independently; (ii) supervised multivariate analysis to evaluate whether our parameters could jointly account for between-group differences (iii) unsupervised multivariate analysis to explore the potential presence of sub-groups. Results Except for general ‘noisier’ (less consistent) decisions in TS, we showed no specific risk-taking behaviour in TS or any relation with tics severity or antipsychotic medication. However, the presence of comorbidities was associated with distortion of decision-making. Specifically, TS with obsessive–compulsive disorder comorbidity was associated with a higher risk-taking profile to increase gain and a higher risk-averse profile to decrease loss. TS with attention-deficit hyperactivity disorder comorbidity was associated with risk-seeking in the ambiguity context to reduce a potential loss. Conclusions Impaired valuation of risk and ambiguity was not related to TS per se . Our findings are important for clinical practice: the involvement of individuals with TS in real-life risky situations may actually rather result from other factors such as psychiatric comorbidities.
Fichier non déposé

Dates et versions

hal-04215563 , version 1 (22-09-2023)

Identifiants

Citer

Cyril Atkinson-Clement, Mael Lebreton, Leïla Patsalides, Astrid de Liege, Yanica Klein, et al.. Decision-making under risk and ambiguity in adults with Tourette syndrome. Psychological Medicine, 2023, 53 (11), pp.5256-5266. ⟨10.1017/S0033291722002318⟩. ⟨hal-04215563⟩
85 Consultations
0 Téléchargements

Altmetric

Partager

More