We investigate the relationship between the long-term (Quaternary) interplate coupling and the short-term geodetically derived interseismic coupling at the Central Ecuador subduction zone. At this nonaccretionary margin, the Cabo Pasado shelf promontory and coastal area are associated with two inter-plate geodetically locked patches. The deepest patch ruptured co-seismically during the Mw7.8-2016 Pedernales earthquake, while the shallowest underwent dominantly after-slip. Marine geophysical and chronostratigraphic data allow reconstructing the Quaternary tectonic evolution of the shelf promontory and substantiating variation of the long-term inter-plate coupling that led to the geodetically locked patches. Prior to ∼1.8 Ma, the outer-wedge inter-plate coupling was strong enough to activate trench-subparallel strike-slip faults. Then, between ∼1.8 and 0.79 Ma, shortening and uplift affected the shelf promontory, implying a locally increased inter-plate coupling. After a short, post-0.79 Ma period of subsidence, shortening and uplift resumed denoting a high inter-plate coupling that endured up to the present. The synchronicity of the structural evolution of the shelf promontory with the subduction chronology of two reliefs of the Carnegie Ridge crest suggests that the locked patches are caused by a geometrical resistance to subduction that propagates landward causing permanent deformation. In 2016, the deepest subducted relief localized stress accumulation and high seismic slip, while the shallowest relief, which is associated with a weakened outer-wedge, prevented updip rupture propagation. Thus, at nonaccretionary margins, active outer-wedge strike-slip faults might be considered a proxy of near-trench coupling, and subducted relief a cause of plate coupling but an obstacle to the tsunami genesis when the relief is shallow.